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A2A Adenosine Receptor Antibodies

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A2A (GP-non-phospho) Adenosine 2A Receptor Antibody, Guinea Pig
A2A (GP-non-phospho) Adenosine 2A Receptor...
The non-phospho-A2A receptor antibody is directed against the distal end of the carboxyl-terminal tail of human A2A. It can be used to detect total A2A receptors in Western blots independent of phosphorylation. The A2A antibody can also...
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Agonist-induced Serine329 phosphorylation of the A2A Adenosine Receptor
pS329-A2A (phospho-A2A Adenosine Receptor...
Serine329 is a major phosphorylation site of the A2A Adenosine receptor. The pS329-A2A antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S329 phosphorylation is a key regulator of A2A...
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Validation of the A2A Adenosine Receptor in transfected HEK293 cells
A2A (non-phospho) Adenosine 2A Receptor Antibody
The non-phospho-A2A receptor antibody is directed against the distal end of the carboxyl-terminal tail of human A2A. It can be used to detect total A2A receptors in Western blots independent of phosphorylation. The A2A antibody can also...
375.00 € *
Details
NEW
Immunohistochemical identification of the A2A Adenosine Receptor in human cortex
A2A (IHC-grade), Adenosine 2A Receptor Antibody
The non-phospho-A2A receptor antibody is directed against the distal end of the carboxyl-terminal tail of human A2A. It can be used to detect total A2A receptors in Western blots independent of phosphorylation. The A2A antibody can also...
375.00 € *
Details

A2A receptor on immune cells (e.g. T cells, NK cells, dendritic cells and macrophages) mediate the immunosuppressive effects of adenosine, an action that produces a powerful tolerogenic/immunosuppressed state. As a result, A2A has been suggested as an immune checkpoint that produces a negative feedback loop in the tumor microenvironment. The A2A receptor primarily couples to Gs proteins ti stimulate adenylyl cyclase. The A2A receptor is constitutively phosphorylated at serine329 (pS329-A2A). Agonist activation enhances S329 phosphorylation. For more information on A2A receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev. 1994 Jun;46(2):143-56. PMID: 7938164; PMCID: PMC4976594.

Fredholm BB, Frenguelli BG, Hills R, IJzerman AP, Jacobson KA, Klotz KN, Linden J, Müller CE, Schwabe U, Stiles GL. Adenosine receptors in GtoPdb v.2021.2. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(2).

A2A receptor on immune cells (e.g. T cells, NK cells, dendritic cells and macrophages) mediate the immunosuppressive effects of adenosine, an action that produces a powerful... read more »
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A2A Adenosine Receptor Antibodies

A2A receptor on immune cells (e.g. T cells, NK cells, dendritic cells and macrophages) mediate the immunosuppressive effects of adenosine, an action that produces a powerful tolerogenic/immunosuppressed state. As a result, A2A has been suggested as an immune checkpoint that produces a negative feedback loop in the tumor microenvironment. The A2A receptor primarily couples to Gs proteins ti stimulate adenylyl cyclase. The A2A receptor is constitutively phosphorylated at serine329 (pS329-A2A). Agonist activation enhances S329 phosphorylation. For more information on A2A receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev. 1994 Jun;46(2):143-56. PMID: 7938164; PMCID: PMC4976594.

Fredholm BB, Frenguelli BG, Hills R, IJzerman AP, Jacobson KA, Klotz KN, Linden J, Müller CE, Schwabe U, Stiles GL. Adenosine receptors in GtoPdb v.2021.2. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(2).

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