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G protein-coupled recptors (GPCRs) and heptahelical receptors (7TMR) are notoriously difficult to detect in fixed tissues using antibodies. For many of these receptors the cellular and subcellular localization remains a major challenge. 7TM Antibodies provides highly-characterized protein binding reagents for selected human and rodent GPCRs, which are well suited for efficient localization in formalin-fixed, paraffin-embedded tissues. Each of these antibodies has gone through advanced validation in transfected cells and native tissues using Western blot and immunohistochemistry. Where ever species cross-reactivity allowed, the verification process included validation using knockout mice (KO-Validated). We strictly adhere to the IUPHAR guidelines for receptor nomenclature.

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Immunohistochemical identification of GPR25 Receptor in small intestine

GPR25 (IHC-grade), G Protein-Coupled Receptor...

The GPR25 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP25. It can be used to detect total GPR25 receptors in Western blots independent of phosphorylation. The GPR25 antibody can...

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Immunohistochemical identification of GPR22 Receptor in Pancreas

GPR22 (IHC-grade), G Protein-Coupled Receptor...

The GPR22 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP22. It can be used to detect total GPR22 receptors in Western blots independent of phosphorylation. The GPR22 antibody can...

375.00 € *

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Immunohistochemical identification of ß1-Adrenoceptor in Heart

β1 (GP-IHC-grade), β1-Adrenoceptor Antibody,...

The non-phospho- β1 antibody is directed against the carboxyl-terminal tail of human β1 . It can be used to detect total β1 receptors in Western blots independent of phosphorylation. The non-phospho- β1 antibody can also be used to...

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Immunohistochemical identification of Atypical Chemokine Receptor 3 in Heart

ACKR3 (GP-IHC-grade), Atypical Chemokine...

The ACKR3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Atypical Chemokine Receptor 3. It can be used to detect total ACKR3 receptors in Western blots independent of phosphorylation. The...

375.00 € *

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KO-Validated

Immunohistochemical identification of G Protein-coupled Receptor 20 in mouse spleen.

mGPR20 (IHC-grade), G Protein-Coupled Receptor...

The GPR20 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse GPR20. It can be used to detect total GPR20 receptors in Western blots independent of phosphorylation. The GPR20 antibody can also be...

375.00 € *

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Immunohistochemical identification of G Protein-coupled Receptor 87 in kidney.

GPR87 (IHC-grade), G Protein-Coupled Receptor...

The GPR87 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP87. It can be used to detect total GPR87 receptors in Western blots independent of phosphorylation. The GPR87 antibody can...

375.00 € *

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Immunohistochemical identification of Atypical Chemokine Receptor 4 in human spleen.

ACKR4 (IHC-grade), Atypical Chemokine Receptor...

The ACKR4 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Atypical Chemokine Receptor 4. It can be used to detect total ACKR4 receptors in Western blots independent of phosphorylation. The...

375.00 € *

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KO-Validated

Immunohistochemical identification of Complement C5a Receptor 1 in human spleen.

mC5a1 (IHC-grade), Complement C5a Receptor 1...

The mouse C5a1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse and rat C5a1. It can be used to detect total C5a1 receptors in Western blots independent of phosphorylation. The mouse C5a1...

375.00 € *

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Immunohistochemical identification of Dopamine Receptor 1 and Dopamine Receptor 2 in striatum

D2 (IHC-grade), Dopamine Receptor 2 Antibody

The D2 receptor antibody is directed against the third intracellular loop of mouse, rat and human D2 dopamine receptor. It detects both the long and short form of D2. It can be used to detect total D2 receptors in Western blots...

375.00 € *

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Immunohistochemical identification of GPR15 Receptor in kidney

GPR15 (IHC-grade), G Protein-Coupled Receptor...

The GPR15 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP15. It can be used to detect total GPR15 receptors in Western blots independent of phosphorylation. The GPR15 antibody can...

375.00 € *

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Immunohistochemical identification of GPR39 Receptor in Small Intestine

GPR39 (IHC-grade), G Protein-Coupled Receptor...

The GPR39 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP39. It can be used to detect total GPR39 receptors in Western blots independent of phosphorylation. The GPR39 antibody can...

375.00 € *

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Immunohistochemical identification of NPSR in Duodenum

NPSR (IHC-grade), Neuropeptide S Receptor Antibody

The NPSR antibody is directed against the distal end of the carboxyl-terminal tail of human Neuropeptide S Receptor. It can be used to detect total NPS receptors in Western blots independent of phosphorylation. The NPSR antibody can also...

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Validation of FLAG-tagged µ-Opioid Receptor in transfected HEK293 cells.

FLAG-Tag, Anti-FLAG Epitope Tag Antibody

The anti-FLAG tag antibody is directed against the sequence DYKDDDDK. The anti-FLAG antibody can be used to detect total receptors in Western blots independent of phosphorylation. The anti-FLAG tag antibody can also be used to isolate...

250.00 € *

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GPR139 (IHC-grade), G protein-coupled Receptor...

The non-phospho-GPR139 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR139. It can be used to detect total GPR139 receptors in Western blots independent of phosphorylation. The GPR139...

375.00 € *

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S1P2 (IHC-grade), Sphingosine 1-Phosphate...

The non-phospho-S1P2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human S1P2. It also detects S1P2 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect total...

375.00 € *

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Immunohistochemical identification of XCR Chemokine Receptor 1 in pancreas

XCR1 (IHC-grade), XCR Chemokine Receptor 1...

The non-phospho-XCR1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human XCR1. It can be used to detect total XCR1 receptors in Western blots independent of phosphorylation. The non-phospho-XCR1...

375.00 € *

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For further reading refer to:

Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2008 Nov;93(11):4519-2 4. doi: 10.1210/jc.2008-1063. Epub 2008 Aug 12. PubMed PMID: 18697876.

Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One. 2008;3(12):e4069. doi: 10.1371/journal.pone.0004069. Epub 2008 Dec 31. PubMed PMID: 19116653; PubMed Central PMCID: PMC2605258.

Lupp A, Hunder A, Petrich A, Nagel F, Doll C, Schulz S. Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4. Neuroendocrinology. 2011;94(3):255-64. doi: 10.1159/000329876. Epub 2011 Sep 27. PubMed PMID: 21952553.

Lupp A, Richter N, Doll C, Nagel F, Schulz S. UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues. Regul Pept. 2011 Feb 25;167(1):9-13. doi: 10.1016/j.regpep.2010.09.004. Epub 2010 Sep 17. PubMed PMID: 20851148.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J. Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide. J Clin Endocrinol Metab. 2013 Nov;98(11):E1730-9. doi: 10.1210/jc.2013-2145. Epub 2013 Oct 3. PubMed PMID: 24092823.

Lee M, Lupp A, Mendoza N, Martin N, Beschorner R, Honegger J, Schlegel J, Shively T, Pulz E, Schulz S, Roncaroli F, Pellegata NS. SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary. Endocr Relat Cancer. 2015 Feb;22(1):111-9. doi: 10.1530/ERC-14-0472. Epub 2014 Dec 16. PubMed PMID: 25515731.

For further reading refer to: Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the... read more »

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For further reading refer to: