Calcitonin Receptor-Like Receptor Antibodies

The calcitonin receptor (CALCR) is a class B G protein-coupled receptor primarily involved in calcium and bone metabolism. Pharmacologically, it is activated by the peptide hormone calcitonin, which leads to inhibition of osteoclast activity and a consequent reduction in bone resorption. Upon ligand binding, CALCR mainly couples to Gs proteins, stimulating adenylate cyclase and increasing intracellular cyclic AMP levels, although coupling to other G proteins and downstream pathways such as phospholipase C signaling has also been described. Signal transduction through CALCR can therefore influence cellular differentiation, survival, and metabolic regulation in target tissues. The receptor is predominantly expressed in osteoclasts, kidney, and certain regions of the central nervous system, reflecting its systemic role in mineral homeostasis and neuroendocrine regulation. Expression levels are regulated by hormonal status, developmental stage, and pathological conditions affecting bone turnover. Due to these properties, CALCR represents a relevant pharmacological target in diseases such as osteoporosis, Paget’s disease, and disorders of calcium metabolism. For more information on CALCR receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Hay DL, Garelja ML, Poyner DR, Walker CS. Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. Br J Pharmacol. 2018 Jan;175(1):3-17. doi: 10.1111/bph.14075. Epub 2017 Nov 28. PMID: 29059473; PMCID: PMC5740251.

Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Amylin: Pharmacology, Physiology, and Clinical Potential. Pharmacol Rev. 2015 Jul;67(3):564-600. doi: 10.1124/pr.115.010629. PMID: 26071095.

Garelja ML, Hay D, Poyner DR, Walker CS. Calcitonin receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F11/2023.1.